Merging process models and plant topology

The paper discusses the merging of first principles process models with plant topology derived in an automated way from a process drawing. The resulting structural models should make it easier for a range of methods from the literature to be applied to industrial-scale problems in process operation and design. © 2011 Zhejiang University

New Insights into Asian Prunus Viruses in the Light of NGS-Based Full Genome Sequencing.

Double stranded RNAs were purified from five Prunus sources of Asian origin and submitted to 454 pyrosequencing after a random, whole genome amplification. Four complete genomes of Asian prunus virus 1 (APV1), APV2 and APV3 were reconstructed from the sequencing reads, as well as four additional, near-complete genome sequences. Phylogenetic analyses confirmed the close relationships of these three viruses and the taxonomical position previously proposed for APV1, the only APV so far completely sequenced. The genetic distances in the respective polymerase and coat protein genes as well as their gene products suggest that APV2 should be considered as a distinct viral species in the genus Foveavirus, even if the amino acid identity levels in the polymerase are very close to the species demarcation criteria for the family Betaflexiviridae. However, the situation is more complex for APV1 and APV3, for which opposite conclusions are obtained depending on the gene (polymerase or coat protein) analyzed. Phylogenetic and recombination analyses suggest that recombination events may have been involved in the evolution of APV. Moreover, genome comparisons show that the unusually long 3' non-coding region (3' NCR) is highly variable and a hot spot for indel polymorphisms. In particular, two APV3 variants differing only in their 3' NCR were identified in a single Prunus source, with 3' NCRs of 214-312 nt, a size similar to that observed in other foveaviruses, but 567-850 nt smaller than in other APV3 isolates. Overall, this study provides critical genome information of these viruses, frequently associated with Prunus materials, even though their precise role as pathogens remains to be elucidated

Failure to act or impossible task? The pursuit of climate justice and energy security through litigation

Frustrated with the lack of a meaningful global response to the inequities wrought by climate change, ordinary citizens and advocacy groups are increasingly turning to legal recourse. They are petitioning the courts to defend their rights, to hold governments and fossil fuel corporations accountable for failure to protect their health, safety and welfare interests from foreseeable natural disasters, and to provide energy security. This chapter discusses the international movement using litigation to redress injustices caused by governments and large companies putting economic benefits in conflict with social, environmental and moral obligations to humanity. As courts become the arena where people look to rectify breaches of climate justice, nations and businesses may ultimately bear a duty of care to reduce carbon emissions with compensation and renewable power sources